Set in South Carolina in 1964, the film is the moving tale of Lily Owens (Fanning) a 14 year-old girl who is haunted by the memory of her late mother (Burton). To escape her lonely life and troubled relationship with her father (Bettany), Lily flees with Rosaleen (Hudson), her caregiver and only friend, to a South Carolina town that holds the secret to her mother's past. Taken in by the intelligent and independent Boatwright sisters (Latifah, Okonedo and Keys), Lily finds solace in their mesmerizing world of beekeeping, honey and the Black Madonna.