Angelina Jolie stars as Evelyn Salt, a CIA officer who swore an oath to duty, honor, and country. When she is accused by a defector of being a Russian sleeper spy, Salt goes on the run to clear her name and ultimately prove she is a patriot. Using all her skills and years of experience as a covert operative, she must elude capture and protect her husband or the world's most powerful forces will erase any trace of her existence.

Liev Schreiber stars as Winter, Salt's boss and friend on the Russian desk at the CIA, and Chiwetel Ejiofor plays Peabody, a CIA counter-intelligence officer.