Derailed is a suspense thriller about ad exec and family man Charles Schine (Clive Owen) who meets business woman, Lucinda (Jennifer Aniston), on the commuter train to Chicago. Flirtation quickly escalates, but their fling turns dangerous when a violent criminal, LaRoche (Vincent Cassel), blackmails them, promising to reveal their indiscretion and threatening their families if they to not pay him. With their lives thrown terrifyingly off-course, they must figure out how to turn the tables on LaRoche and save their families.