Margaret Keane (Adams), the painter whose distinctive creations featuring big-eyed children became one of art's first mass-market success stories in the 1950s. In the 1960s, Margaret Keane's artwork was sold under the name of her husband of the time, Walter Keane (Waltz), her second husband. Many reasons might be put forward to explain this, but it was also one of the reasons they divorced. Not wanting to relinquish the rights to the artwork, Walter and Margaret's divorce proceeding went all the way to Federal court. At the hearing, Margaret painted in front of the judge to prove her point. Walter declined to paint before the court, citing a sore shoulder. In 1965, the courts sided with her, enabling her to paint under her own name.
The cast includes Christoph Waltz, Amy Adams, Krysten Ritter, Jason Schwartzman, Danny Huston and Terence Stamp.