Now, Professor Jones has returned home to Marshall College – only to find things have gone from bad to worse. His close friend and dean of the college (Jim Broadbent) explains that Indy's recent activities have made him the object of suspicion, and that the government has put pressure on the university to fire him. On his way out of town, Indiana meets rebellious young Mutt (Shia LaBeouf), who carries both a grudge and a proposition for the adventurous archaeologist: If he'll help Mutt on a mission with deeply personal stakes, Indy could very well make one of the most spectacular archaeological finds in history – the Crystal Skull of Akator, a legendary object of fascination, superstition and fear.

But as Indy and Mutt set out for the most remote corners of Peru – a land of ancient tombs, forgotten explorers and a rumored city of gold – they quickly realize they are not alone in their search. The Soviet agents are also hot on the trail of the Crystal Skull. Chief among them is icy cold, devastatingly beautiful Irina Spalko (Cate Blanchett), whose elite military unit is scouring the globe for the eerie Crystal Skull, which they believe can help the Soviets dominate the world... if they can unlock its secrets.

Indy and Mutt must find a way to evade the ruthless Soviets, follow an impenetrable trail of mystery, grapple with enemies and friends of questionable motives, and, above all, stop the powerful Crystal Skull from falling into the deadliest of hands.