Krista's body is found by Arden (Toni Collette), a lonesome caretaker living with her irascible mother (Piper Laurie). This leads to Leah (Rose Byrne), a forensics graduate student whose sister went missing as a child, stumbling upon possible closure when Krista's body appears on her gurney. The story continues with Ruth (Mary Beth Hurt), who in the midst of a long and intense love/hate relationship with her husband (Nick Searcy), discovers a disturbing connection between her husband and Krista's murder. Finally, Melora (Marcia Gay Harden) is a mother searching for answers about her runaway daughter Krista’s troubled life and finds help in her quest from another troubled young woman (Kerry Washington).