Among his American motion picture credits are Mr. and Mrs. Smith, Holes, K-19: The Widowmaker, Arachnid, Along Came A Spider, The Shrink Is In, Octopus, The Omega Code The Jackal, The Saint, Hamlet, GoldenEye, Hackers and Back in the U.S.S.R.

On television, he has appeared in the series Commander in Chief, Without a Trace, Alias, The Agency, JAG and Buffy the Vampire Slayer.

Born in Moscow, Isyanov was part of a cultural exchange between the Moscow Art Theatre and Britain's Royal Shakespeare Company in the late 1980s. He was later invited to study at the British American Drama Academy and then joined the Theatre Clwyd in Wales, performing in a season of Russian plays. Following the 1991 collapse of the Soviet Union, Isyanov remained in England, performing with the English Shakespeare Company and the Moving Theatre Company, and teaching at the Drama Centre London, before relocating to the U.S.