Piper Perabo has been working non-stop since her big-screen splash in Jerry Bruckheimer's Coyote Ugly. She was recently seen in Adam Shankman's Cheaper By The Dozen 2, in which she reprised her role as the eldest daughter to Steve Martin and Bonnie Hunt; in the romantic comedy Imagine Me & You with Lena Heady and Matthew Goode; and in the crime drama 10th & Wolf with an ensemble cast that includes James Marsden and Dennis Hopper. She next stars in Because I Said So with Diane Keaton, Mandy Moore and Lauren Graham. Also in the wings is First Snow, a film directed by Mark Fergus, costarring Guy Pearce and Adam Scott. Perabo is currently filming an untitled Pastor Brothers project for Paramount Vantage in New Mexico. She will play the female lead opposite Chris Pine and Lou Taylor Pucci in the post-apocalyptic thriller about four friends trying to escape a viral pandemic. The film is set to release in 2007.

Perabo's feature film debut was in the comedy White Boyz, written by Danny Hoch. She also starred in comedy caper The Adventures Of Rocky And Bullwinkle opposite Robert De Niro and Renee Russo, George and the Dragon with Michael Clark Duncan and James Purefoy, the cult favorite Lost and Delirious directed by Lea Pool, and the sci-fi thriller The Cave, opposite Cole Hauser, Morris Chestnut and Lena Headey.