Famke Janssen co-starred in the independent film The Treatment opposite Sir Ian Holm. She recently reprised her role on the FX original drama series Nip/Tuck. Janssen received a Movieline Breakthrough Award for her star turn on the show and the provocative drama received outstanding critical acclaim as well as an AFI Award and Golden Globe nomination for season one.

Janssen collaborated with director Robert Altman on The Gingerbread Man. She toplined Hide and Seek, a psychological suspense thriller opposite Robert DeNiro and Dakota Fanning for Twentieth Century Fox. Janssen starred with Debra Winger in the film Eulogy, which premiered at the 2004 Sundance Film Festival and was released later that year.

In 2002, Janssen starred opposite Eddie Murphy and Owen Wilson in I Spy for director Betty Thomas. She starred in Gary Fleder's thriller Don't Say a Word opposite Michael Douglas for Twentieth Century Fox/Regency and in Jon Favreau's Made in which she co-starred with Favreau and Vince Vaughn.

Janssen earned critical acclaim for her star-making performance opposite Jon Favreau in Valerie Breiman's Love and Sex, which premiered at the 2000 Sundance Film Festival. She starred opposite Geoffrey Rush in House on Haunted Hill, and in Robert Rodriguez' The Faculty, John Dahl's Rounders and Woody Allen's Celebrity.

In addition, Janssen played a lower-class Irish-American Bostonian, opposite Denis Leary, Martin Sheen and Billy Crudup, in Ted Demme's Monument Avenue. She also starred, with Harvey Keitel, in John Irvin's City of Industry, and in Stephen Sommers's Deep Rising. Janssen previously starred as the lasciviously lethal assassin, 'Xenia Onatopp,' in the James Bond megahit Goldeneye.