Meloni is well known to television audiences for his portrayal of the duplicitous inmate Chris Keller on HBO’s hard-hitting critically praised series "Oz." Additionally, he has appeared in a series of memorable guest-starring roles on some of network television’s most acclaimed series such as "Homicide: Life on the Street" as well as "NYPD Blue," in which Meloni played Jimmy Liery, the volatile undercover target of Emmy Award-winner Kim Delaney’s Detective Russell. Meloni also starred in the series "Leaving L.A.,"several miniseries including "In A Child’s Name" and "Mario Puzo’s The Last Don," and the telefilms "Shift" and "Dominick Dunne Presents: Murder in Greenwich."

Meloni’s film credits include "Runaway Bride" in which he appeared as Julia Roberts’ fiancé. He has also been seen in such diverse films as "Bound," "12 Monkeys," "Junior," "Fear and Loathing in Las Vegas" and "Wet Hot American Summer," co-starring Janeanne Garofalo and David Hyde Pierce. Meloni also appeared in the 2004 comedy "Harold & Kumar Go to White Castle."

An avid traveler, Meloni has explored from Turkey to Bali and is searching for points in-between to visit. He also enjoys weightlifting, playing basketball, football, and chess and is a martial arts enthusiast. Meloni resides in New York with his wife and daughter.